---
title: "Principal Machine Learning Engineer at Amgen – Remote"
canonical: "https://www.metaintro.com/job/principal-machine-learning-engineer-at-amgen-8467f0e4-69af-5f34-bac0-e3cd72974118"
language: "en"
author: "Metaintro"
---

[![Amgen logo](/api/favicon-proxy?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dwww.amgen.com%26sz%3D128)](/company/amgen)[Amgen](/company/amgen)
# Principal Machine Learning Engineer at Amgen

Compensation · Listed in posting

$187,395 – $253,535/yr

**Setup**
: Remote

**Type**
: Full-time

**Level**
: staff+

**Posted**
: Sep 25, 2026

## Description

Amgen is hiring a Principal Machine Learning Engineer to own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud and on-premises environments. The role builds and operates production machine-learning and generative-AI solutions, including ML pipelines, LLM/RAG systems, observability, evaluation, drift detection, automated retraining, and full-stack AI applications. The principal will also establish AI strategy, mentor teams, translate business needs into roadmaps, and partner with DevOps, Security, Compliance, and Product teams. The position requires a doctorate with two years of machine-learning engineering experience or equivalent higher education and experience combinations, plus at least two years of people-management or leadership experience, and offers a U.S. base salary range of 187,395.25 to 253,534.75 USD.

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