---
title: "Principal Manufacturing… at Amgen – Holly Springs, NC"
canonical: "https://www.metaintro.com/job/principal-manufacturing-systems-engineer-upstream-downstream-process-e107cd2f-a501-5583-93b1-db6ecfd6693c"
language: "en"
author: "Metaintro"
---

[![Amgen logo](/api/favicon-proxy?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dwww.amgen.com%26sz%3D128)](/company/amgen)[Amgen](/company/amgen)
# Principal Manufacturing Systems Engineer – Upstream/Downstream Process Automation at Amgen

**Location**
: Holly Springs, North Carolina

**Type**
: Full-time

**Level**
: lead/mgmt

**Posted**
: Sep 8, 2026

## Description

Amgen is hiring a Principal Manufacturing Systems Engineer focused on upstream and downstream bioprocessing automation. The role supports the design, construction, commissioning, qualification, operational readiness, and ongoing 24/7 support of automation systems for drug substance manufacturing, including Emerson DeltaV DCS, process control, GMP compliance, data integrity, change control, and technical leadership. The position requires a doctorate with two years of engineering experience or an equivalent combination of education and experience, plus two years of managerial or team-leadership experience, and offers up to 10% domestic or international travel.

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