Senior Director, Head of Quantitative Systems Pharmacology at Moderna

Compensation

$196,700 – $353,400/yr

Setup: Hybrid
Type: Full-time
Level: Senior

Description

Modernra is looking for a Senior Director, Head of Quantitative Systems Pharmacology (QSP) to lead strategic, scientific, and operational efforts in mechanistic and systems pharmacology. The role involves defining and executing visions for mechanistic modeling, systems biology, and model-informed drug development (MIDD) applications across various stages of drug development. This leader will collaborate with internal and external stakeholders, drive QSP strategy, and represent Moderna as a thought leader in QSP and translational modeling.

Required Skills

Mechanistic Modeling
Systems Biology
Model-informed Drug Development
MATLAB/SimBiology
Monolix
R
Python

Additional Information

Required Previous Experiences: 10+ years of industry or equivalent experience in QSP / mechanistic modeling, with at least 5 years in oncology and/or immunology.
Proven track record of applying mechanistic and translational models to support drug development (preclinical through clinical).
Experience contributing to regulatory filings and Health Authority interactions leveraging model-informed approaches.
Preferred Qualifications: Experience in mRNA or novel therapeutic modalities (e.g. gene therapy, biologics, immuno-oncology).
Familiarity with PBPK modeling, virtual populations, or digital-twin simulation.
Experience building infrastructure or toolchains for scalable modeling and data integration.
Track record of scientific publications and external visibility.