Senior Scientist, Small Molecule Screening at flagshippioneeringinc

Department: Research/DiscoveryEducation: education_required

Compensation · Listed in posting

$126,000 – $181,500/yr

Location: Cambridge, Minnesota
Type: Full-time
Level: senior
Posted: Sep 24, 2026

Description

Flagship Labs 129 is recruiting a Senior Scientist to help build a novel DNA-encoded small molecule drug-discovery platform. The role involves designing, constructing, and validating DNA-encoded libraries; performing affinity-based selections against protein targets; deconvoluting and validating screening hits; optimizing workflows; and translating experimental data into actionable insights. The position requires strong DNA-compatible chemistry, DEL screening, hit deconvolution, and validation experience, with additional cheminformatics, CRO, and laboratory-automation experience preferred. The role offers a salary of $126,000 to $181,500, healthcare coverage, an annual incentive program, retirement benefits, and other benefits.

Required Skills

DEL design
DNA chemistry
Affinity selection
Hit deconvolution
Cheminformatics
LC-MS
Enzymatic ligation

Additional Information

Required Previous Experiences: Strong track record in DNA-encoded library design, synthesis, and affinity-based selection
Deep experience with DNA-compatible chemistry and hit deconvolution and validation
Preferred Qualifications: Ph.D. in organic chemistry, medicinal chemistry, chemical biology, or a similar field with 5+ years of industry or postdoctoral experience
End-to-end DEL screening experience from library design through hit deconvolution
Hands-on DNA-compatible chemistry and split-and-pool synthesis
Encoding, tagging, enzymatic ligation, and LC-MS quality control
Affinity selection formats and controls
On-DNA and off-DNA hit validation
CRO management experience
Cheminformatics, droplet screening, microfluidics, and laboratory automation
Translation Company Name: Flagship Pioneering, Inc.